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目的探讨甲状腺球蛋白抗体(TG-Ab)、甲状腺过氧化物酶抗体(TPO-Ab)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)对自身免疫性甲状腺疾病(AITD)的临床应用价值。方法采用化学发光免疫分析法定量检测153例自身免疫性甲状腺疾病患者、74例非自身免疫性甲状腺疾病患者和71例健康对照组血清中的TG-Ab、TPO-Ab、FT3、FT4。结果不同自身免疫性甲状腺疾病患者之间和自身免疫性甲状腺疾病患者与非自身免疫性甲状腺疾病患者及正常健康人群之间其TG-Ab、TPO-Ab、FT3、FT4水平差异有统计学意义。AITD组TG-Ab和TPO-Ab水平与非AITD组、健康对照组比较差异有统计学意义(P<0.01),桥本甲状腺炎组TG-Ab和TPO-Ab水平与Graves病组比较差异有统计学意义(P<0.01),桥本甲亢组和Graves病组FT3、FT4水平差异无统计学意义(P>0.05),而TPO-Ab、TG-Ab差异有统计学意义(P<0.01)。结论 TG-Ab、TPO-Ab、FT3、FT4四项指标对AITD的诊断及鉴别诊断有重要临床意义。
Objective To investigate the effects of thyroglobulin antibody (TG-Ab), thyroid peroxidase antibody (TPO-Ab), free triiodothyronine (FT3) and free thyroid hormone (FT4) on autoimmune thyroid disease ) Clinical value. Methods The serum levels of TG-Ab, TPO-Ab, FT3 and FT4 in 153 patients with autoimmune thyroid disease, 74 patients with non-autoimmune thyroid disease and 71 healthy controls were detected by chemiluminescence immunoassay. Results There were significant differences in TG-Ab, TPO-Ab, FT3 and FT4 levels between patients with different autoimmune thyroid diseases and between patients with autoimmune thyroid disease and non-autoimmune thyroid disease and normal healthy people. The levels of TG-Ab and TPO-Ab in AITD group were significantly different from those in non-AITD group and healthy control group (P <0.01). There was significant difference between the Hashimoto’s thyroiditis group and Graves’ disease group (P <0.01). The levels of FT3 and FT4 in Hashimoto’s Hyperthyroidism group and Graves’ disease group were not significantly different (P> 0.05), but the difference of TPO-Ab and TG-Ab was statistically significant . Conclusion The four indexes of TG-Ab, TPO-Ab, FT3 and FT4 have important clinical significance in the diagnosis and differential diagnosis of AITD.