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目的:探讨C反应蛋白(CRP)水平与糖尿病患者动脉粥样硬化(A S)程度的关系。方法:选择经彩色多普勒超声检查的50例糖尿病合并下肢血管病变(LEDA)患者,按下肢A S的程度分为内膜增厚组(A组),斑块形成组(B组)。50例健康体检者作为正常对照组(C组)。均测定血清CRP和空腹血糖(FBG),并分析与动脉内膜增厚、斑块之间的相关性。结果:内膜增厚组和斑块形成组的血CRP的浓度显著高于对照组。斑块形成组的CRP的浓度显著高于内膜增厚组。A组与B组间空腹血糖差异无统计学意义。结论:血清CRP与糖尿病患者A S的发生有关,CRP与糖尿病患者A S的严重程度相关。
Objective: To investigate the relationship between the level of C-reactive protein (CRP) and the degree of atherosclerosis (A s) in diabetic patients. Methods: Fifty patients with diabetic lower extremity vascular disease (LEDA) who underwent color Doppler ultrasonography were divided into the intima-thickening group (A group) and the plaque-forming group (group B) according to the degree of lower extremity A s. 50 healthy subjects as normal control group (C group). Serum CRP and fasting blood glucose (FBG) were measured, and the correlation between the intima thickening and plaque was analyzed. Results: The concentration of CRP in intima-thickening group and plaque-forming group was significantly higher than that in control group. The plaque formation group CRP concentration was significantly higher than the intimal thickening group. There was no significant difference in fasting plasma glucose between group A and group B. Conclusion: Serum CRP is associated with the occurrence of A S in diabetic patients, and CRP is associated with the severity of A S in diabetic patients.