本文报告160例临床确诊的肝硬化病人采用ELISA法检测多项HBV血清学标记,结果抗-HBc、HBsAg阳性率分别为75％及71.9％,检测结果中特别有意义的是有较高的抗-HBe阳性率(50％),表明病人多感染时间已较长。抗-HBcIgM、PHSAR、HBeAg阳性率分别为25％、21.1％及16％,提示尚有相当一部分病人仍存在有病毒复制和传染性。将肝硬化病人和同期的急、慢肝病人相比较更表明我国肝硬化病人的发生主要和慢性HBV感染有关,并有进一步发展为肝细胞癌的可能。 This article reports 160 cases of clinically diagnosed patients with cirrhosis using ELISA to detect a number of HBV serological markers, the results of anti-HBc, HBsAg positive rates were 75% and 71.9%, the test results of particular interest is a higher anti- -HBe positive rate (50%), indicating that the patient has been infected for a long time. Anti-HBcIgM, PHSAR, HBeAg positive rates were 25%, 21.1% and 16%, suggesting that there are still a considerable number of patients still exist virus replication and contagious. Comparison of patients with cirrhosis and acute and chronic liver disease in the same period shows that the occurrence of cirrhosis in our country is mainly related to chronic HBV infection and further development of hepatocellular carcinoma.