1983年首次由Warren和Marshall在胃粘膜中分离出幽门螺杆菌(Hp),许多早期的研究致力于该菌的体外培养及致病学。近年来分子生物学的迅猛发展,使得Hp的分类学也有了长足进展,这种分类学是基于DNA水平上的,可以从菌株水平鉴定Hp,从而追踪Hp的传染源,研究其传播途径,探讨Hp的分布 Helicobacter pylori (Hp) was first isolated from gastric mucosa by Warren and Marshall in 1983, and many early studies focused on the in vitro culture and pathology of the bacteria. In recent years, the rapid development of molecular biology makes great progress in the taxonomy of Hp. This taxonomic study is based on the DNA level, and Hp can be identified from the strain level so as to trace the source of Hp infection and to explore its route of transmission Hp distribution