198 6年 Murry发现反复短暂缺血可以减轻心肌随后较长时间缺血损伤 [1 ] ,从而首次提出了缺血预适应的概念 ,这一概念的提出为缺血心肌的保护及其机制的探索开辟了一个崭新的领域。十余年来尽管研究人员已提出了缺血预适应可能是通过刺激心脏合成与释放内源性保护物质 ,随后激 198 6 Murry found that repeated short-term ischemia can reduce myocardial ischemia followed by a longer period of injury [1], which for the first time put forward the concept of ischemic preconditioning, the concept proposed for the protection of ischemic myocardium and its mechanism Opened up a whole new field. For more than ten years, although researchers have proposed that ischemic preconditioning may be by stimulating the synthesis and release of endogenous protective substances in the heart,