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目的 探讨p2 7蛋白在乳腺癌中的表达及其意义。方法 采用免疫组织化学法检测 8例正常乳腺组织、2 4例良性乳腺疾病组织、66例乳腺癌组织 p2 7蛋白的表达 ,探讨与临床病理学特征的关系。 结果 正常乳腺组织和良性乳腺疾病组织中 p2 7蛋白的表达率为 10 0 .0 % ( 3 2 /3 2 ) ,癌组织为 5 3 .0 % ( 3 5 /66) ;p2 7蛋白表达与肿瘤临床分期、淋巴结转移、局部复发、远处转移显著相关。结论 p2 7蛋白的表达与乳腺癌的临床病理学特征密切相关 ,可能是判断乳腺癌预后的 1项重要指标。
Objective To investigate the expression of p27 in breast cancer and its significance. Methods Immunohistochemical method was used to detect the expression of p27 protein in 8 cases of normal breast tissue, 24 cases of benign breast disease and 66 cases of breast cancer, and to explore the relationship with the clinicopathological features. Results The positive rates of p27 protein in normal and benign breast tissues were 100.0% (3 2/3) and 53.0% (35/66), respectively. The positive rates of p27 and Tumor clinical stage, lymph node metastasis, local recurrence, distant metastasis was significantly correlated. Conclusion The expression of p27 protein is closely related to the clinicopathological features of breast cancer, which may be an important index to judge the prognosis of breast cancer.