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７３例恶性肿瘤，应用含高度致吐作用的ＤＤＰ、ＤＴｌＣ、ＣＴＸ和ＡＤＭ等药联合化疗，随机分组给予止吐剂。Ⅰ组单用枢复宁，Ⅱ组单用吗丁琳，Ⅲ组枢复宁与吗丁琳合用。结果表明Ⅰ组的恶心、呕吐（包括急性和迟发性呕吐）控制良好，疗效优于Ⅱ组，但与Ⅲ组比较无明显差异。三组发生副反应者均少见，偶见腹胀、腹泻、便秘、头痛或头昏，患者可以耐受。由此提示，枢复宁作为高选择性强效５－ＨＴ３受体拮抗剂与外周多巴胺受体拮抗剂吗丁琳有协同止吐作用，可在临床上推广。
Totally 73 malignant tumors were treated with DDP, DTlC, CTX and ADM with high degree of vomiting, and were given antiemetic randomly. Group Ⅰ alone Ning Fu, Ⅱ alone with Ding Lin, Ⅲ group of Ning Fu Ning and Ning Ding combination. The results showed that group Ⅰ nausea and vomiting (including acute and delayed vomiting) control well, the effect is superior to Ⅱ group, but with no significant difference compared with the group Ⅲ. Three groups were side effects were rare, occasionally bloating, diarrhea, constipation, headache or dizziness, patients can tolerate. This suggests that, pivalate as a highly selective and potent 5-HT3 receptor antagonist with the peripheral dopamine receptor antagonist you Dinglin synergistic antiemetic effect, which can be clinically promoted.