论文部分内容阅读
丙硫异烟胺(Prothioamide)是第二线抗结核药。本文报道其药理与毒性研究结果。实验采用小白鼠、大白鼠和猫。药物配成5％混悬液一次或重复(每天给药,共30天)灌胃。对照组喂以生理盐水。结果表明,以0.1克/公斤给药后,小白鼠的活动次数减少3/4以上;剂量为0.5～1.0克/公斤时,经30～45分钟,全部动物的协调活动丧失,骨骼肌的张力降低,几小时后,动物处于侧卧状丙硫异烟胺(Prothioamide)是第二线抗结核药。本文报道其药理与毒性研究结果。实验采用小白鼠、大白鼠和猫。药物配成5％混悬液一次或重复(每天给药,共30天)灌胃。对照组喂以生理盐水。结果表明,以0.1克/公斤给药后,小白鼠的活动次数减少3/4以上;剂量为0.5～1.0克/公斤时,经30～45分钟,全部动物的协调活动丧失,骨骼肌的张力降低,几小时后,动物处于侧卧状
Prothioamide is a second-line anti-TB drug. This article reports its pharmacological and toxicological findings. Experiments using mice, rats and cats. Drug dubbed a 5% suspension once or repeated (daily administration, a total of 30 days) gavage. Control group fed with saline. The results showed that after 0.1 g / kg administration, the number of motility in mice decreased by 3/4 or above. When the dose was 0.5-1.0 g / kg, the coordination activities of all animals were lost after 30-45 minutes, and the tension of skeletal muscle Reduced, a few hours later, the animal was in the lateral position Prothioamide is the second-line anti-TB drug. This article reports its pharmacological and toxicological findings. Experiments using mice, rats and cats. Drug dubbed a 5% suspension once or repeated (daily administration, a total of 30 days) gavage. Control group fed with saline. The results showed that after 0.1 g / kg administration, the number of motility in mice decreased by 3/4 or above. When the dose was 0.5-1.0 g / kg, the coordination activities of all animals were lost after 30-45 minutes, and the tension of skeletal muscle Lower, a few hours later, the animal is lying sideways