药物常可根据对受体作用的性质区分为激动剂、部分激动剂拮抗剂,而pD_2,pD′_2与pA_2可分别作为鉴别这类性质,并可定量估计药物对受体的亲和力。该方法对阐明药物效应与化学结构之间的关系占有很重要地泣。从离体器官实验所得剂量与反应关系可应用电子计算机分析其作用性质,并获得药物对受体亲和力的定量标志pD_2、pA_2及pD′_2。该方法可避免传统的繁琐计算,而代以客观、快速相正 Drugs can often be divided into agonists and partial agonist antagonists according to the nature of the receptors, while pD_2, pD’_2 and pA_2 can be used to identify these properties, respectively, and the drug affinity can be estimated quantitatively. This method is very important for clarifying the relationship between the drug effect and the chemical structure. The relationship between dose and response in vitro experiment can be analyzed by computer and the quantitative indicators of drug affinity to receptor such as pD_2, pA_2 and pD’_2 were obtained. This method can avoid the traditional cumbersome calculation, and replace it with objective, fast and correct