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本文报告4例接触硅患者发生快速进行性肾功能衰竭,其中3例有结缔组织病表现。患者均有不正常的蛋白尿、低白蛋白血症和活动性尿沉渣。肾组织学检查,光镜:局灶和节段性肾小球细胞增多,硬化有新月小体,间质中细胞浸润和肾小管坏死伴有红细胞管型。电镜:足突消失、细胞胞浆有特征性电子密度溶酶体,微小管和电子密度沉着物。尽管积极治疗,2例患者死于全身性疾病,1例进展为终末期肾病而
This report reports 4 patients with silicosis of rapid progressive renal failure, of which 3 cases of connective tissue disease performance. Patients have abnormal proteinuria, hypoalbuminemia and urinary sediment. Renal histological examination, light microscopy: focal and segmental glomerular cells increased, sclerosis crescentosome, interstitial infiltration of cells and tubular necrosis associated with red blood cell tube. Electron microscopy: foot process disappears, cytoplasm has characteristic electron density of lysosomes, microtubules and electron density deposits. Despite active treatment, 2 patients died of systemic disease and 1 patient progressed to end stage renal disease