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目的分析不同年龄的暴露后人群接种2-1-1程序辽宁成大速达水剂人用狂犬病疫苗的安全性。方法临床观察对象按照<21岁,21~岁,≥51岁3个年龄组以1∶1∶1的比例各300人共900人随机分为观察组和对照组,观察组采用Zagreb 2-1-1方案4剂次免疫程序,对照组采用传统5剂次免疫程序接种狂犬病疫苗,比较两组对象整体及不同年龄段在疫苗接种后所有全身和局部症状的发生率的差异。结果在整体反应中,观察组疲倦乏力、触痛发生率较对照组低,且具有统计学意义(P<0.05),其余观察症状发生率对比无统计学意义;在不同年龄段的差异中,<21岁年龄组中,观察组在发热、疲倦乏力、头晕、触痛、硬结、红肿的反应中与对照组发生率比较差异无统计学意义(P≥0.05);21~岁年龄组中,观察组疲倦乏力、触痛发生率较对照组低,差异有统计学意义(P<0.05),其余观察症状发生率比较差异无统计学意义;≥51岁年龄组中观察组触痛发生率较对照组低,差异有统计学意义(P<0.05),其余观察症状发生率比较差异无统计学意义。结论采用Zagreb 2-1-1方案4剂次免疫程序接种辽宁成大速达人用狂犬病疫苗具有较高的临床安全性,值得推广。
Objective To analyze the safety of human rabies vaccines of Liaoning Chengda Suntah lotion inoculated with 2-1-1 program of different age groups after exposure. Methods The clinical observation subjects were randomly divided into observation group and control group according to a total of 900 people of 300 in a ratio of 1: 1: 1 in three age groups of <21 years old, 21 years old and ≥51 years old. The observation group was treated with Zagreb 2-1 -1 program 4 doses of immunization program, the control group vaccinated rabies vaccine by conventional 5 doses of immunization program to compare the overall and different age groups in both groups after vaccination all the systemic and local differences in the incidence of symptoms. Results In the overall response, the observation group was wearable, the incidence of tenderness was lower than that of the control group (P <0.05), and the incidence of the other observed symptoms was not statistically significant. Among the different age groups, In the 21-year-old group, there was no significant difference in the incidence of fever, fatigue, dizziness, tenderness, induration, red and swollen between the observation group and the control group (P≥0.05) The observation group was wearable, the incidence of tenderness was lower than that of the control group, the difference was statistically significant (P <0.05), the other observation symptoms were no significant difference in the incidence; The control group was low, the difference was statistically significant (P <0.05), the remaining observed symptoms were no significant difference in the incidence. Conclusion Vaccination with rabies vaccine Zagreb 2-1-1 for 4 rabies vaccines in Liaoning Province has high clinical safety and is worth popularizing.