新生儿皮下坏疽是新生儿常见的急性皮下感染，属中医“痈、发”范畴。常见于生后5～10天发病，病变皮肤可红肿、硬、热、触痛，范围可迅速扩大，若不及时处理，可因败血症或合并肺炎而死亡。我们自1992年以来，采用大黄末外敷治疗早期新生儿皮下坏疽50例，长者6天，短者3天，全 Neonatal subcutaneous gangrene is a common newborn acute subcutaneous infection, is a Chinese “痈, hair” category. Common in 5 to 10 days after birth morbidity, skin lesions can be inflamed, hard, hot, tenderness, the scope can be rapidly expanded, if not treated, may be due to sepsis or pneumonia and died. Since 1992, we have applied rhubarb topical treatment of early neonatal subcutaneous gangrene in 50 cases, the elderly 6 days, the short 3 days, all