核因子κB(NFκB)是一种广泛存在于机体各种细胞中的核转录因子,可以被多种细胞外刺激活化,参与免疫和炎性反应、细胞内信号传递、调控多种基因表达。近年来研究发现,在糖尿病肾病(DN)发生发展中,氧化应激、糖基化终末产物、蛋白激酶C以及肾素血管紧张素系统等都直接或间接参与了NFκB活化。因此,了解NFκB在DN发病机制中的作用,有助于对该病的临床防治。 Nuclear factor κB (NFκB) is a nuclear transcription factor widely found in various cell types. It can be activated by many extracellular stimuli and involved in immune and inflammatory responses, intracellular signaling, and regulation of multiple gene expressions. In recent years, studies found that in the development of diabetic nephropathy (DN), oxidative stress, advanced glycation end products, protein kinase C and renin angiotensin system are directly or indirectly involved in NFκB activation. Therefore, to understand the role of NFκB in the pathogenesis of DN contribute to the clinical prevention and treatment of the disease.