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本文用分光光度滴定法测定了单-[6-(1-吡啶)-6-脱氧]-α-和γ-环糊精(1)和(3)与一系列氨基酸在磷酸缓冲溶液中(pH=7.20),25.0～40.0℃时形成超分子体系的稳定常数,进而计算了配位焓和配位熵,并与单-[6-(1-吡啶)-6-脱氧]-β-环糊精(2)的实验结果作了比较.化学计量法表明,所有的氨基酸均与环糊精衍生物形成了1:1的超分子体系.从热力学的观点,讨论了化学修饰环糊精和客体氨基酸的尺寸或形状适合、疏水效应、范德华力和氢键等几种弱相互作用力对形成超分子体系的贡献.研究结果发现,具有正电荷环糊精衍生物的吡啶基,作为一种分子探针不仅可以识别氨基酸生物分子的尺寸或形状之间的差异,而且还可以识别L/D-型手性对映体之间的差异,进一步表明了主-客体间的诱导楔合、几何互补在分子受体选择性键合底物形成超分子体系中的重要作用.
In this paper, spectrophotometric titration was used to determine the interaction between mono- [6- (1-pyridyl) -6-deoxy] -α- and γ-cyclodextrin (1) and (3) with a series of amino acids in phosphate buffer solution = 7.20). The stability constant of supramolecular system was formed at 25.0 ~ 40.0 ℃. The enthalpy and coordination entropy of the supramolecular system were calculated and compared with the single - [6- (1-pyridyl) -6-deoxy] The experimental results of Jing (2) were compared, and the stoichiometry showed that all the amino acids formed a 1: 1 supramolecular system with cyclodextrin derivatives. From the thermodynamic point of view, the chemical modification of cyclodextrins and guest Amino acid size or shape suitable, hydrophobic effect, van der Waals forces and hydrogen bonds and several other weak interactions on the contribution of the formation of supramolecular system.The results showed that, with a positive charge of cyclodextrin derivatives pyridyl, as a molecule The probes not only recognize differences in size or shape of amino acid biomolecules but also identify differences between L / D-type chiral enantiomers, further demonstrating host-guest induced wedging, geometric complementation It plays an important role in the formation of supramolecular systems by selective bonding of substrates to molecular receptors.