茄科植物洋金花(Datura metel)是一个广泛分布于印度的普通药用植物。早在1903年就曾报道含有生物碱成分,1987年发现在它的叶中存在茄交酯(Withanolide)类成分。本文介绍从洋金花叶子中分到了一个新的茄交酯类化合物,命名为开联茄曼陀灵(Secowithametelin)(2)。干燥粉碎的植物用石油醚(bp60～80℃)脱酯,氯仿提取,其提取物经硅胶柱层析,石油醚—乙酸乙酯(3:1)洗脱,得到(2),经石油醚—乙酸乙酯 The solanaceous plant Datura metel is a common medicinal plant widely distributed in India. Alkaloids have been reported as early as 1903. In 1987, there was the presence of the Withanolide in their leaves. This article describes the distribution of a new eggplant lactone compound from the leaves of Datura sinensis, named Secowithametelin (2). The dried and crushed plants were deesterified with petroleum ether (bp 60-80°C) and extracted with chloroform. The extracts were subjected to silica gel column chromatography and eluted with petroleum ether-ethyl acetate (3:1) to give (2) as petroleum ether. Ethyl acetate