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据报道,患重症疟疾时蛋白酶抑制剂抗凝血酶III(ATIII)显著减少。作者对重度感染文氏疟原虫(P.vinkei)的小鼠补充ATIII代用品,观察对生存率和生存时间的影响。实验采用无特殊病原体(SPF)的NMRI小鼠,经腹腔接种疟原虫。将感染鼠随机分
It has been reported that the protease inhibitor antithrombin III (ATIII) is significantly reduced in patients with severe malaria. The authors supplemented ATIII surrogates to P.vinkei heavily infected mice and observed the effect on survival and survival time. In the experiment, NMRI mice without special pathogens (SPF) were used to inoculate Plasmodium intraperitoneally. Infected mice were randomized