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特发性血小板减少性紫瘢(ITP)的皮肤表现包括四肢、上胸、颈部的紫癜和粘膜出血。皮肤色素沉着未有过报道。本文报告1例46岁妇女,患有慢性ITP32年。反复发生牙龈出血、下肢紫瘢、血尿和月经过多。予脾脏切除(包括副脾切除)、强的松和细胞毒制剂(氮芥、长春新碱和环磷酰胺)等均无效。一年来出现小腿皮肤弥漫性深褐色改变,无有关的药物治疗或者过度日光暴露史。色素沉着为深棕色,以膝盖、腓肠肌部位、踝和足背为主。血象基本正常,骨髓检查符合ITP诊断。血清铁79μg/dl,总
Skin manifestations of idiopathic thrombocytopenic purpura (ITP) include limbs, upper thoracic, purpura of the neck, and mucosal bleeding. Skin pigmentation has not been reported. This article reports a 46-year-old woman with chronic ITP for 32 years. Repeated gingival bleeding, lower limb purple scar, hematuria and menorrhagia. Spleen resection (including splenectomy), prednisone and cytotoxic agents (nitrogen mustard, vincristine and cyclophosphamide) and so on are invalid. Over the year there was diffuse dark brown skin calf changes, no related medications or excessive exposure to sunlight. Pigmentation dark brown to the knee, gastrocnemius parts, ankle and dorsal foot-based. Blood as normal, bone marrow examination in line with ITP diagnosis. Serum iron 79μg / dl, total