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目的探讨ATM基因rs664143单核苷酸多态性与食管癌发生风险之间的关系。方法收集157例食管癌患者及125例健康体检者标本,用基因测序技术检测ATM基因rs664143单核苷酸多态性,并用非条件Logistic回归统计分析其与食管癌发生风险的相关性。结果吸烟史(OR=2.672,95%CI:1.620～4.406,P<0.01)和肿瘤家族史(OR=2.249,95%CI:1.072～4.722,P<0.01)为食管癌的危险性因素。与A/A基因型比较,G/G型增加患食管癌的风险(OR=1.408,95%CI:0.571～3.469),A/G杂合子是降低患食管癌的保护性因素(OR=0.937,95%CI:0.521～1.686),但均无统计学意义。结论 ATM基因rs664143位点多态性在食管癌发生过程中起重要作用。
Objective To investigate the relationship between the single nucleotide polymorphism of ATM gene rs664143 and the risk of esophageal cancer. Methods A total of 157 esophageal cancer patients and 125 healthy controls were collected for gene sequencing. The single nucleotide polymorphisms of rs664143 in ATM gene were detected by non-conditional Logistic regression. The correlations were analyzed with the risk of esophageal cancer. Results The smoking history (OR = 2.672, 95% CI: 1.620-4.406, P <0.01) and family history of cancer (OR = 2.249,95% CI: 1.072-4.222, P <0.01) were the risk factors of esophageal cancer. Compared with the A / A genotype, G / G increased the risk of esophageal cancer (OR = 1.408, 95% CI: 0.571-3.469), and A / G heterozygotes reduced the risk of esophageal cancer (OR = 0.937 , 95% CI: 0.521 ~ 1.686), but no statistical significance. Conclusion The rs664143 polymorphism of ATM gene plays an important role in the carcinogenesis of esophageal cancer.