论文部分内容阅读
目的探讨上颌骨纤维结构不良样及骨母细胞瘤样型骨肉瘤的临床病理特征、诊断及鉴别诊断要点。方法对1例上颌骨纤维结构不良样及骨母细胞瘤样型骨肉瘤的临床表现、影像学特征、组织学形态、免疫组化进行分析,并复习相关文献。结果肿瘤由骨纤维结构不良样区域及骨母细胞瘤样骨肉瘤区域组成,瘤细胞异型性小,核分裂少见,瘤组织中见肿瘤性成骨。免疫组化示肿瘤细胞MDM2和CDK 4(+)。结论颌骨纤维结构不良样及骨母细胞瘤样骨肉瘤为低度恶性肿瘤。应与颌骨纤维结构不良、骨母细胞瘤及骨化性纤维瘤相鉴别,MDM2和CDK4二者联合用在其鉴别诊断中具有重要价值。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of osteosarcoma in osteoblastoma with poorly fibrous maxillary structure. Methods One case of fibrous tissue defect of the maxilla and the osteosarcoma osteosarcoma osteosarcoma were analyzed in terms of clinical manifestations, imaging features, histology and immunohistochemistry, and reviewed the related literatures. Results The tumor consisted of poorly differentiated bone-like fibrous regions and osteoblastoma-like osteosarcoma. The tumor cells were rarely characterized by atypia and were rare in mitosis. Tumor osteogenesis was seen in the tumor tissue. Immunohistochemistry showed tumor cells MDM2 and CDK 4 (+). Conclusion The poor structure of mandibular fibrosis and osteoblastoma osteosarcoma are low-grade malignant tumors. Should be differentiated from the fibrous structure of the jawbone, osteoblastoma and ossifying fibroma, MDM2 and CDK4 combination of both used in the differential diagnosis of great value.