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应用生物素—亲和素—酶联免疫吸附法（BA－ELISA）测定了36例喉癌病人血清谷胱甘肽S—转移酶（GST）的含量。结果表明．喉癌患者术前血清GST水平明显高于正常人（P＜0．01），与临床分期明显相关，Ⅲ、Ⅳ期患者显著高于Ⅰ、Ⅱ期患者（P＜0．05），与淋巴结转移、病理分级无关．手术切除肿瘤后血清GST水平迅速下降，术后14天恢复正常。提示血清GST可诈为喉癌的标志酶，监测血清GST浓度的变化对观察疗效和判断预后有重要意义。
Serum glutathione S-transferase (GST) levels were measured in 36 patients with laryngeal cancer using biotin-avidin-ELISA method. The results show. The preoperative serum GST level in patients with laryngeal cancer was significantly higher than that in normal people (P <0.01), and was significantly correlated with clinical stage. The patients in stage Ⅲ and Ⅳ were significantly higher than those in stage Ⅰ and Ⅱ (P <0.05) Metastasis, pathological grade has nothing to do. Surgical resection of the tumor serum GST levels decreased rapidly after 14 days returned to normal. Tip serum GST can be deceived for the sign of laryngeal enzymes, monitoring serum GST concentration changes in the observation of efficacy and prognosis of great significance.