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目的：正确认识抗庚型肝炎病毒（ＨＧＶ）抗体和ＨＧＶ－ＲＮＡ的临床诊断价值。方法：用ＥＬＩＳＡ和逆转录ＰＣＲ方法同时检测９０例儿童抗ＨＧＶ抗体和ＨＧＶ－ＲＮＡ。结果：抗ＨＧＶ阳性率为１５６％（１４／９０），其中慢性丙型肝炎中（丙肝）占１０／２８，慢性乙型肝炎中（乙肝）占４／１２；ＨＧＶ－ＲＮＡ阳性率占２４４％（２２／９０），其中丙肝中占１２／２８，乙肝中占４／１２，非甲－戊肝炎中占２／４，急性黄疸型肝炎中占２／４，肾炎或肾病中占２／２０。２２例健康儿童均阴性。抗ＨＧＶ阳性者中ＨＧＶ－ＲＮＡ阳性率为１４３％（２／１４），丙氨酸转氨酶（ＡＬＴ）异常率为５７１％；ＨＧＶ－ＲＮＡ阳性者中的抗ＨＧＶ阳性率为９１％（２／２２），ＡＬＴ异常率为４５５％，两组比较Ｐ＞００５。结论：要想全面了解ＨＧＶ感染率，此两种方法都应采用；抗ＨＧＶ阳性可能预示病毒复制停止；病毒血症与肝功能损害的临床联系具有多样性，需动态观察。
Objective: To correctly understand the diagnostic value of anti-hepatitis G virus (HGV) antibody and HGV-RNA. Methods: 90 children with anti-HGV antibody and HGV-RNA were detected simultaneously by ELISA and reverse transcription PCR. Results: The positive rate of anti-HGV was 156% (14/90), including 10/28 in chronic hepatitis C (hepatitis C) and 4/12 in chronic hepatitis B (HGV-RNA) 24.4% (22/90), of which 12/28 in hepatitis C, 4/12 in hepatitis B, 2/4 in non-hepatitis E and 2/4 in acute jaundice, nephritis or nephropathy 2 / 20.22 healthy children were negative. The positive rate of HGV-RNA in anti-HGV positive patients was 143% (2/14) and that of alanine aminotransferase (ALT) was 571%. The positive rate of anti-HGV in HGV-RNA positive patients was 9 1% (2/22), ALT abnormal rate was 455%, P> 005 in both groups. CONCLUSIONS: Both methods should be used in order to fully understand the HGV infection rate. Anti-HGV positivity may predict the cessation of viral replication. The clinical link between viremia and liver dysfunction is diverse and requires dynamic observation.