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目的 研究丝裂霉素缓释剂（ Ｍ Ｍ Ｃ Ｓ Ｒ Ｐ） 在大鼠和狗体内的药代动力学。方法 用高效液相色谱法（ Ｈ Ｐ Ｌ Ｃ） 测定血浆丝裂霉素 Ｃ（ Ｍ Ｍ Ｃ） 的浓度。结果 大鼠皮下植入 Ｍ Ｍ Ｃ Ｓ Ｒ Ｐ 后， Ｍ Ｍ Ｃ 可持续、缓慢释放；犬肌肉植入０４ ｍｇ·ｋｇ－ １ Ｍ Ｍ Ｃ Ｓ Ｒ Ｐ 后，其有效血浆浓度曲线呈一室模型特点，其维持有效血浆浓度时间（００１ ｍｇ· Ｌ－ １） 为２４０ ｈ ，其峰值浓度仅为ｉｖ 同剂量 Ｍ Ｍ Ｃ 的２７ ％ 。结论 Ｍ Ｍ Ｃ Ｓ Ｒ Ｐ 有显著的缓释作用。
Objective To study the pharmacokinetics of mitomycin C (MMC) in rats and dogs. Methods Plasma concentrations of mitomycin C (M M C) were determined by high performance liquid chromatography (HPLC). Results M M C S R P was implanted subcutaneously in rats, and M M C sustained and slowly released. After implanted with 0.4 mg · kg -1 M M C S R P in dogs, the effective plasma concentration curve showed a Room model features, its maintenance of effective plasma concentration time (0 01 mg · L-1) was 240 h, the peak concentration of only iv with the same dose of M M C 27%. Conclusion M M C S R P has a significant sustained release effect.