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很久以来就推论遗传因素在十二指肠溃疡(简称DU)病中起重要作用,因为在一级亲属中其发病率增高。但迄今尚无识别本病的有力的遗传标志。已知DU者中O型血和唾液中不分泌ABH抗原的频率较高,但其间相关性较差。Edwards推算ABO位点在DU全部变量中约占1％,而上述分泌状态者约占1.5％。本期杂志中,Rotter等报告血清胃蛋白酶元I(简称PGI)含量增高呈常染色体显性遗传,而且和DU相关。在二个大家族中,有本特点人的子代约1/2PGI增高,无本特点者其子代均无PGI的增高。前者
It has long been corroborated that genetic factors play an important role in duodenal ulcer disease (DU) because of an increased incidence in first-degree relatives. But so far no strong genetic markers to identify the disease. Known DU who O-type blood and saliva do not secrete ABH antigen higher frequency, but during the poor correlation. Edwards predicts that the ABO locus will account for about 1% of all DU variables, and about 1.5% of these secreted states. In this issue of the journal, Rotter et al. Reported an elevated serum pepstatin I (PGI) content that was autosomal dominant and associated with DU. In the two large families, the characteristics of the offspring of about 1 / 2PGI increased, no characteristics of their offspring without PGI increased. former