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目的:了解连云港地区不同HPV亚型的分布情况及不同亚型引起宫颈癌的风险度。方法:采用凯普快速导流杂交技术检测1 699例有性生活妇女的21种HPV亚型分型,对其中98例高危亚型携带者行TCT检查和阴道镜下取组织活检。结果:1 699例受检者中共检出17种亚型,检出率为12.83%,其中前5位亚型依次为HPV58、52、16、33、18,其感染率分别为22.0%(48/218)、13.3%(29/218)、13.3%(29/218)、11.5%(25/218)和10.1%(22/218)。经TCT细胞学和组织病理学检查发现原位癌和LSIL癌前病变各2例。结论:连云港地区HPV亚型感染分布以58、52和16型为主,其分布与癌前病变及宫颈癌有密切相关性。
Objective: To understand the distribution of different HPV subtypes in Lianyungang and the risk of cervical cancer caused by different subtypes. Methods: 21 HPV subtypes of 1 699 women with sex life were detected by CAPP, and TCT and colposcopy biopsies were performed on 98 high risk subtypes. Results: A total of 1799 subtypes were detected in 1 699 subjects with a detection rate of 12.83%. Among them, the top five subtypes were HPV58, 52, 16, 33, and 18, with infection rates of 22.0% (48 /218), 13.3% (29/218), 13.3% (29/218), 11.5% (25/218) and 10.1% (22/218). TCT cytology and histopathological examination found in situ carcinoma and LSIL precancerous lesions in 2 cases. Conclusion: The distribution of HPV subtypes in Lianyungang is mainly 58, 52 and 16, and its distribution is closely related to precancerous lesions and cervical cancer.