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口服给药途径是最简便的给药方法,但某些药物由于对胃壁的不良反应,使应用受到限制。作者认为,寻找加入制剂中能排除或降低药物对胃损害的各种赋料很有意义。作者以解热镇痛消炎药甲氧萘丙酸(Naproxen)为主药进行实验研究。实验将主药与亲水性或疏水性不同赋料(原文表1,2,从略)制成9种处方,分别研磨匀化,选用体重为200～250gr的Sprague-Dawley种雄鼠作胃损害试验。混悬剂的制备是秤取主药及各种赋料研混后,以400倍显微镜检查,粒度应小于20μ。
Oral route of administration is the most convenient method of administration, but some drugs due to adverse reactions to the stomach wall, so that the application is limited. The authors believe it makes sense to look for additional ingredients that can eliminate or reduce drug damage to the stomach. The author with antipyretic analgesic anti-inflammatory drug Naproxen as the main drug experimental study. Experiments will be the main drug and hydrophilic or hydrophobic different materials (original table 1, 2, omitted) made of 9 kinds of prescription, respectively, grinding uniform, select the weight of 200 ~ 250gr Sprague-Dawley male rats for stomach Damage test. Suspension preparation is to take the main drug and various materials after grinding, 400 times the microscope, the particle size should be less than 20μ.