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目的:筛选乳糖微粉研磨改性降低白芷提取物吸湿性的工艺条件,分析乳糖微粉的抗吸湿机制。方法:以吸湿率为评价指标,采用单因素试验考察乳糖种类、药辅比、研磨时间对乳糖微粉研磨改性以降低白芷提取物吸湿性的工艺条件,通过粒径分布、微观结构等物理指标对改性物加以佐证。结果:乳糖微粉研磨改性最佳工艺条件为白芷提取物与乳糖超微粉(粉碎1 min)等比例研磨3 min。改性物的粒径d0.1,d0.5,d0.9分别为3.477,15.078,54.501μm,接触角(7.7±0.66)度,乳糖颗粒包覆在白芷提取物表面。结论:乳糖适度微粉化能明显降低白芷提取物的吸湿初速度与吸湿加速度的绝对值,能显著降低白芷提取物的吸湿性。抗吸湿作用可能与研磨改性使得乳糖粒子附于白芷提取物表面密切相关。
OBJECTIVE: To screen the process conditions for reducing the hygroscopicity of Angelica dahurica extract by grinding modification of lactose micro-powder, and to analyze the anti-hygroscopic mechanism of lactose micro-powder. Methods: The moisture absorption rate was taken as the evaluation index. The single factor test was used to investigate the technical conditions of lactose micro-powder modified by grinding and lactose to reduce the hygroscopicity of the Angelica dahurica extract. Modified to be confirmed. Results: The optimum conditions of grinding and modifying lactose micro-powder were that Angelica dahurica extract and lactose superfine powder (crushed for 1 min) were grinded for 3 min. The particle size of the modified substance d0.1, d0.5, d0.9 were 3.477,15.078,54.501μm, contact angle (7.7 ± 0.66) degrees, lactose particles coated on the surface of Angelica dahurica extract. CONCLUSION: The moderate micronization of lactose can significantly reduce the absolute value of the initial moisture absorption rate and moisture absorption rate of Angelica dahurica extract, which can significantly reduce the hygroscopicity of Angelica dahurica extract. Anti-hygroscopicity may be closely related to grinding modification so that lactose particles attached to the surface of Angelica extract.