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【目的】探讨血浆同型半胱氨酸（Homocysteine ，Hcy）水平检测对原发性高血压（Essential hyperten-sion ，ES）患者患冠心病的诊断价值。【方法】从2011年5月至2013年4月，对本院173例确诊为ES病患者进行冠脉造影检查。由冠脉造影检查结果分为高血压组（A组，76例）和高血压与冠心病并发组（B组，97例）；检测两组患者的 Hcy水平并进行分析比较。另外以血浆内 Hcy含量15μmol/L为分界值，比较不同Hcy水平患者发生冠心病的概率。【结果】通过Hcy水平比较发现B组患者 Hcy水平为（21．1±7．9）μmol/L ，明显高于A组（14．0±4．5）μmol/L ，且两组相比较差异有显著性（ P＜0．05）。另外以血浆内Hcy含量15μmol/L为分界值，得出Hcy正常组患冠心病概率为35．1％，比Hcy偏高组患冠心病概率67．7％明显更低，且两组相比较差异有显著性（ P＜0．05）。【结论】Hcy水平检测对ES发展为冠心病的概率具有一定的预测价值。“,”[Objective] To explore the value of plasma homocysteine (Hcy) in the diagnosis of coronary heart dis-ease in patients with essential hypertension (ES) .[Methods] A total of 173 patients diagnosed as ES in our hospital from May 2011 to April 2013 underwent coronary angiography examination .According to coronary angiography ex-amination results ,all patients were divided into hypertension group (group A ,n =76) and hypertension combined with coronary heart disease group (group B ,n=97) .The levels of Hcy in two groups were measured and compared . When plasma Hcy (15μmol/L ) was taken as the cut-off value ,the probability of coronary heart disease in patients with different level of Hcy was compared .[Results]The level of Hcy in group B was 21 .1 ± 7 .9?mol/L ,which was obviously higher than that in group A (14 .0 ± 4 .5μmol/L) ,and there was significant difference between two groups ( P <0 .05) .When plasma Hcy(15μmol/L) was taken as the cut-off value ,the probability of coronary heart disease in patients with normal Hcy was 35 .1% ,which was obviously lower than that in high Hcy group (67 .7% ) ,and there was significant difference between two groups ( P<0 .05) .[Conclusion]Hcy level is valuable for predicting the probability of ES developing to coronary heart disease .