论文部分内容阅读
目的:了解参麦注射液对改善消化道肿瘤化疗后不良反应的临床疗效。方法:依据西医诊断标准、WHO临床疗效评定标准,选取60例胃癌术后予DOF方案化疗的患者随机分为两组,治疗组予化疗期间与参麦注射液+对症支持治疗,对照组化疗期间尽予对症支持治疗。按WHO的评价标准,评价化疗后不良反应的情况。结果:治疗组与对照组在性别、年龄、治疗前KPS、肿瘤类型临床分期比较,差异均无统计学意义(P>0.05)。治疗一周期后,外周血骨髓抑制、外周神经毒性、胃肠道反应的发生率及发生程度,两组经秩和差异有统计学意义(P<0.05);结论:参麦注射液能明显的改善消化道肿瘤化疗后所产生的不良反应。
Objective: To understand the clinical efficacy of Shenmai injection in improving the adverse reactions of gastrointestinal tumors after chemotherapy. Methods: According to the diagnostic criteria of Western medicine and WHO criteria for clinical curative effect, 60 patients with DOF chemotherapy after gastric cancer surgery were randomly divided into two groups. The patients in the treatment group received Shenmai injection + symptomatic and supportive therapy during the chemotherapy and the patients in the control group during chemotherapy Give symptomatic supportive treatment. According to WHO evaluation criteria, evaluate the adverse reactions after chemotherapy. Results: There was no significant difference between the treatment group and the control group in terms of gender, age, KPS before treatment and clinical stage of tumor type (P> 0.05). After one cycle of treatment, peripheral blood bone marrow suppression, peripheral neurotoxicity, the incidence of gastrointestinal reactions and the degree of occurrence, the two groups by the rank sum difference was statistically significant (P <0.05); Conclusion: Shenmai injection can significantly Improve gastrointestinal cancer chemotherapy after the adverse reactions.