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本研究采用深冷冻同种胚胎骨(DFHBB)对下颌骨缺损的修复进行了实验研究。采用日本成年大耳白兔26只,分为DFHBB移植组、新鲜自体骨(FAB)移植组及空白对照组。分别于2、4、8、12、24、48周时间处理动物后,采用X线摄片、组织学、同位素扫描、电子计算机伪彩色处理、密度量测以及扫描电镜观察。结果表明DFHBB移植后从组织学、血管相、计算机密度量测动态曲线均可见两2周和第4周,骨生长愈合过程稍早于自体骨,后期与自体骨愈合过程基本相似。但与空白对照组比较有显著性差异。本文对DFHBB与FAB移植后愈合过程进行了比较,同时讨论DFHBB移植的生物学、抗原性、骨诱导作用及其修复下颌骨缺损的意义。
In this study, deep frozen allograft embryos (DFHBB) were used to study the repair of mandibular defects. Twenty-six adult Japanese white rabbits were divided into DFHBB transplantation group, fresh autologous bone graft group and blank control group. After 2, 4, 8, 12, 24 and 48 weeks, animals were treated with X-ray, histology, isotope scanning, electronic computer pseudo-color processing, density measurement and scanning electron microscope. The results showed that the histological, vascular, and computer densities measured after DFHBB transplantation showed that the dynamic process of bone growth was observed two weeks and four weeks earlier, and the process of bone growth healing was earlier than autologous bone. But compared with the blank control group, there are significant differences. In this paper, we compared the healing process of DFHBB and FAB after transplantation, and discussed the biological, antigenic and osteoinductive effects of DFHBB transplantation and its significance in the repair of mandibular defects.