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全反式维甲酸(ATRA)诱导急性早幼粒细胞白血病(APL)过程中出现外周血白细胞增多及浸润等生物学行为改变的机制尚不清楚。我们应用酶联免疫吸附实验(ELISA)及流式细胞仪分别检测ATRA诱导过程中APL患者血浆中基质细胞衍生因子-1α(SDF-1α)及APL细胞上CXCR4[CXCR4是以趋化因子结
The mechanism by which all-trans retinoic acid (ATRA) induces changes in biological behavior such as leukocytosis and infiltration in acute promyelocytic leukemia (APL) remains unclear. We used enzyme-linked immunosorbent assay (ELISA) and flow cytometry to detect plasma levels of stromal cell-derived factor-1alpha (SDF-1alpha) and APL cell CXCR4 in APL patients induced by ATRA [CXCR4 is a chemokine-