With the support by the National Natural Science Foundation of China and National Science and Technology Major Project,the research team led by Prof.Lan Lefu at the State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,and Prof.Li Jian(李剑)at the Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science With the support by the National Natural Science Foundation of China and National Science and Technology Major Project, the research team led by Prof. Lan Lefu at the State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Prof .Li Jian at the Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science