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摘要目的评估复发缓解型多发性硬化的病人钆布醇的累积剂量和平扫T1WI上齿状核和苍白球信号强度(SI)的关系。方法在27周、96~98周、168周多次静脉注射0.1 mmol/kg钆布醇,同时评估齿状核/脑桥、苍白球/丘脑的信号/强度比和肝肾功能,比较多次注射后的SI比率与钆布醇注射总量、注射间隔时间之间的关系。结果在多次注射钆布醇后苍白球/丘脑(P=0.025)和齿状核/脑桥(P<0.001)的SI比
Abstract Objective To evaluate the relationship between cumulative doses of gadobutrol in patients with relapsing-remitting multiple sclerosis and signal intensity (SI) of the dentate nucleus and globus pallidus on T1WI. Methods 0.1 mmol / kg gadobutrol was intravenously injected for 27 weeks, 96-98 weeks and 168 weeks. The signal / intensity ratio of dentate / pontine / globus pallidus / thalamus and liver / kidney function were also evaluated. Multiple injections After SI ratio and the total amount of gadobutrol injection, the relationship between the injection interval. Results The SI ratio of globus pallidus / thalamus (P = 0.025) and dentate / pontine (P <0.001) after multiple injections of gadobutrol