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本文报道了四[2-甲氧基异丁基异腈]络铜(Ⅰ)氟硼酸盐(Cu(MIBl)_4BF_4)的合成和心肌灌注显像剂~(99)Tc~m-2-甲氧基异丁基异腈(~(99)Tc~m-MIBl)的制备研究及初步动物实验结果。Cu(MIBI)_4BF_4是一白色晶体,经IR,NMR,MS和元素分析等测定,结果与结构完全一致。讨论了pH值、Cu(MIBI)_4BF_4用量、FSA用量及~(99)Tc~mO_4~-洗脱液体积、加热时间对~(99)Tc~m-MIBI标记率的影响。以Cu(MIBI)_4BF_4为原料制成的一步法冻干药盒,标记率大于90％,经动物实验和初步临床应用,证明该药盒使用简单方便,稳定性好,是很有前途的心肌灌注显像剂。
This paper reports the synthesis of tetrakis [2-methoxyisobutyronitrile] copper (I) fluoroborate (Cu (MIBl) 4BF_4) and the effect of myocardial perfusion imaging agent 99Tc-m- Preparation of (- 99) Tc ~ m - MIBI and Preliminary Animal Experimental Results. Cu (MIBI) _4BF_4 is a white crystal. The results are in good agreement with the results of IR, NMR, MS and elemental analysis. The effects of pH value, Cu (MIBI) _4BF_4 dosage, FSA dosage, volume of ~ (99) Tc ~ mO_4 ~ eluent and heating time on the labeling efficiency of ~ (99) Tc ~ m-MIBI were discussed. The one-step freeze-dried kit made of Cu (MIBI) _4BF_4 is more than 90%. The animal experiment and preliminary clinical application show that the kit is simple, convenient and stable, and it is a promising myocardial Perfusion imaging agent.