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目的观察三维适形放疗联合甘氨双唑钠(CMNa)对高龄食道癌患者的增敏作用及不良反应。方法 2009年7月～2011年7月收治的老年食道癌患者50例,随机分为研究组和单纯放疗组,每组25例,研究组:CMNa800mg/m2+0.9%氯化钠100ml于放疗前60min内输入,3次/周。两组患者均行三维适形放疗,DT62～64Gy/31～32F。比较两组的近期疗效及不良反应。结果研究组近期有效率为68%,单纯放疗组为44%(P﹤0.05);两组患者不良反应比较差异无统计学意义。结论 CMNa可以提高老年食道癌患者病灶放射敏感性,3DCRT联合CMNa治疗不能耐受化疗的高龄患者近期疗效好,不良反应小。
Objective To observe the sensitizing effect and side effects of three-dimensional conformal radiotherapy combined with glycididazole sodium (CMNa) on elderly esophageal cancer patients. Methods Fifty elderly patients with esophageal cancer who were admitted to our hospital from July 2009 to July 2011 were randomly divided into study group (n = 25) and radiotherapy alone group (study group). CMU 800 mg / m 2 + 0.9% sodium chloride 100 ml 60min input, 3 times / week. Two groups of patients underwent three-dimensional conformal radiotherapy, DT62 ~ 64Gy / 31 ~ 32F. The two groups were compared the short-term efficacy and adverse reactions. Results The recent effective rate was 68% in the study group and 44% in the radiotherapy alone group (P <0.05). There was no significant difference in adverse reactions between the two groups. Conclusions CMNa can improve the radiosensitivity of esophageal cancer in elderly patients. The elderly patients with 3DCRT and CMNa who can not tolerate chemotherapy have better curative effect and less adverse reactions.