Angew.Chem.Int.Ed.2017,56,116~121轴手性的联二芳基骨架不仅存在于许多天然产物和生物活性分子中,而且还是许多重要手性催化剂的核心骨架.该类轴手性骨架的催化不对称构建存在着一些挑战性问题.例如,大部分反应的催化体系都采用金属/手性配体,手性有机小分子催化的反应很少;构建的轴手性联二芳基骨架主要局限于联苯、联萘、苯基萘等,而含有杂芳环的 Angew.Chem.Int.Ed.2017,56,116-121 Axis The chiral biaryl skeleton is not only found in many natural and biologically active molecules, but also as the core skeleton of many important chiral catalysts. For example, most of the catalytic systems used were metal / chiral ligands, and chiral small organic molecules catalyzed the reaction very little. The structure of the shaft chiral diaryl Skeleton is mainly limited to biphenyl, binaphthyl, phenyl naphthalene, etc., while containing heteroaromatic ring