心肌损伤、心脏缺血再灌注损伤等常常是由活性氧自由基引起的,其导致的一系列心功能障碍、慢性心脏疾病是影响人类健康的重大杀手。核因子相关因子2(Nrf2)是近几年发现的体内抗氧化应激的重要转录因子,具有抗炎、抗凋亡、抗增殖、保护心肌细胞等作用。本文就其在心肌损伤中的作用研究进展作一概述。 Myocardial damage, heart ischemia-reperfusion injury, etc. are often caused by reactive oxygen species, which led to a series of cardiac dysfunction, chronic heart disease is a major killer affect human health. Nuclear factor-related factor 2 (Nrf2) is an important transcription factor of antioxidant stress in vivo found in recent years. It has anti-inflammatory, anti-apoptosis, antiproliferation and cardiomyocyte protection. This article gives an overview of its role in myocardial injury.