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目的:观察口服雷公藤多甙加潘生丁对治疗过敏性紫癜性肾炎的疗效。方法:回顾性调查并随访2003—2006年用雷公藤多甙加潘生丁治疗50例小儿过敏性紫癜性肾炎为治疗组,并随机选择同期患儿口服单剂雷公藤多甙30例作为对照。结果治疗组治愈44例(88%),有效6例(12%),对照组治愈18例(60%),有效12例(40%),两组间差异显著(P<0.05),对蛋白尿、血尿、高血压及水肿疗效亦差异显著(均为P<0.01)。结论:提示雷公藤多甙加潘生丁治疗小儿过敏性紫癜性肾炎优于单剂雷公藤多甙,值得临床应用。
Objective: To observe the efficacy of oral tripterygium glycosides plus dipyridamole in the treatment of allergic purpura nephritis. Methods: Retrospective investigation and follow-up 2003-2006 with Tripterygium glycosides plus dipyridamole treatment of 50 cases of children with Henoch-Schonlein purpura nephritis as the treatment group and random selection of children during the same period single oral dose of Tripterygium glycosides 30 as a control. Results In the treatment group, 44 cases (88%) were cured, 6 cases (12%) were effective, 18 cases (60%) were cured and 12 cases (40%) were effective in the control group. Urine, hematuria, hypertension and edema were also significantly different (all P <0.01). Conclusion: Tip Tripterygium glycosides plus dipyridamole treatment of children with Henoch-Schonlein purpura nephritis is superior to single-dose tripterygium glycosides, it is worth clinical application.