对革兰氏阴性菌有活性和能抗β-内酰胺酶的头霉素类是一类有价值的抗生素,其中噻吩甲氧头孢菌素和羟羧氧酰胺头孢菌素已应用于临床。最近又发现了Sulfazecin(4)和有关的Monobactam抗生素。本文报道,通过薛夫氏硷的环合作用简便合成3-甲氧基-3-氨基-2-氮杂环丁酮类化合物的方法,此法是具有头霉素类型侧链的β-内酰胺一步合成法的首例。合成路线 Gram-negative bacteria active and resistant to β-lactamase of the cephamycins is a class of valuable antibiotics, of which thiophene methoxy cephalosporins and hydroxycarboxamide cephalosporins have been used clinically. Recently Sulfazecin (4) and related Monobactam antibiotics have also been found. This paper reports a simple and convenient method for the synthesis of 3-methoxy-3-amino-2-azetidinones by cycloaddition of Strychnine, which is a β-endo Amide one-step synthesis of the first case. synthetic route