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目的通过观察急性高血压脑出血患者血清基质金属蛋白酶-9(MMP-9)水平的变化,探讨其临床检测价值。方法血清MMP-9采用ELISA法定量检测。结果急性高血压脑出血患者组血清MMP-9为(58.73±19.15)ng/mL,对照组(19.42±6.55)ng/mL,两组差异有统计学意义(P<0.01)。患者中大量出血者血清MMP-9为(74.05±17.49)ng/mL,小量出血者(37.41±19.51)ng/mL,两组差异有统计学意义(P<0.01)。意识不清者血清MMP-9为(71.30±18.72)ng/mL,意识清醒者(35.85±19.06)ng/mL,两组差异有统计学意义(P<0.01)。血清MMP-9异常组的死亡率为28.3%,血清MMP-9正常组的死亡率为11.1%,两组差异有统计学意义(P<0.01)。血清MMP-9水平预测发生死亡的灵敏度为61.9%。结论血清MMP-9定量测定可作为判断高血压脑出血急性期病情轻重、评价发生意外的一项客观指标。
Objective To investigate the changes of serum matrix metalloproteinase-9 (MMP-9) levels in patients with acute hypertensive intracerebral hemorrhage (ICH) and explore their clinical value. Methods Serum MMP-9 was detected by ELISA. Results The serum levels of MMP-9 in patients with acute hypertensive intracerebral hemorrhage were (58.73 ± 19.15) ng / mL and those in control group (19.42 ± 6.55) ng / mL, respectively. There was significant difference between the two groups (P <0.01). The serum levels of MMP-9 in patients with massive hemorrhage were (74.05 ± 17.49) ng / mL and those with minor hemorrhage (37.41 ± 19.51) ng / mL, respectively. There was significant difference between the two groups (P <0.01). The level of serum MMP-9 in conscious people was (71.30 ± 18.72) ng / mL and conscious people (35.85 ± 19.06) ng / mL respectively. There was significant difference between the two groups (P <0.01). The mortality of abnormal MMP-9 in serum was 28.3%, and the mortality of normal MMP-9 in serum was 11.1%. There was significant difference between the two groups (P <0.01). The sensitivity of serum MMP-9 levels to predict death was 61.9%. Conclusion The quantitative determination of serum MMP-9 can be used as an objective indicator to evaluate the severity of hypertensive intracerebral hemorrhage in acute stage.