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研究了人工合成的谷胱甘肽过氧化物酶（ＧＳＨＰｘ）模拟物－ｅｂｓｅｌｅｎ及其辅助因子谷胱甘肽（ＧＳＨ）对Ｃｕ２＋及紫外线（ＵＶ）诱导的低密度脂蛋白（ＬＤＬ）氧化修饰的抑制和终止作用。结果显示：在ＧＳＨ存在的情况下，低主５－μｍｏｌ／Ｌ的ｅｂｓｅｌｅｎ就可完全抑制由５μｍｏｌ／ＬＣｕ２＋引发的ＬＤＬ氧化修饰，单独的ｅｂｓｅｌｅｎ和ＧＳＨ没有抑制作用，５０μｍｏｌ／Ｌ的维生素Ｅ只有很微弱的抑制作用。Ｅｂｓｅｌｅｎ对Ｃｕ２＋引发的ＬＤＬ氧化修饰的抑制作用时间的长短与ＧＳＨ的浓度有关。对已由Ｃｕ２＋引发启动的ＬＤＬ氧化修饰，加入ｅｂｓｅｌｅｎ和ＧＳＨ可防止其进一步的氧化。Ｅｂｓｅｌｅｎ和ＧＳＨ对紫外线引起的ＬＤＬ氧化修饰也有一定的抑制作用。
The effects of glutathione (GSH), a synthetic glutathione peroxidase (GSHPx) mimic named ebselen, and its cofactor glutathione (GSH) on the oxidative modification of Cu2 + and UV-induced low density lipoprotein Suppression and termination effect. The results showed that low main 5-μmol / L ebselen could completely inhibit the oxidative modification of LDL induced by 5μmol / L LCu2 + in the presence of GSH, while ebselen and GSH alone had no inhibitory effect, and only 50μmol / L of vitamin E Weak inhibition. The inhibitory effect of Ebselen on Cu2 + -induced LDL oxidation was related to the concentration of GSH. Oxidative modification of LDL that has been primed by Cu2 + priming, adding ebselen and GSH prevents further oxidation. Ebselen and GSH also have some inhibitory effects on UV-induced LDL oxidation.