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目的探讨雷米普利与缬沙坦的单用及联用治疗原发性高血压(EH)的临床疗效观察。方法102例轻中度的EH患者,随机分成3组,雷米普利组(34例)予雷米普利5mg/d;缬沙坦组(34例)予缬沙坦160mg/d;合用组(34例)予雷米普利2.5mg加缬沙坦80mg/d,疗程均为12周。治疗前后定期测血压、动态血压、肝肾功能、血脂、血糖等,观察不良反应发生情况。结果雷米普利组总有效率77.1%,降压幅度23.9/15.8mmHg;缬沙坦组总有效率77.1%,降压幅度24.3/15.1mmHg;联用组总有效率79.4%,降压幅度24.4/15.2mmHg。3组药物均可降低血压负荷,其降低值组间比较无显著性差异(P>0.05)。3个用药组治疗前后血常规、生化、血脂、肝肾功能均无明显变化(P>0.05),总不良反应率组间比较无显著性差异。结论雷米普利与缬沙坦联用治疗EH可有效、安全地降压。
Objective To investigate the clinical efficacy of ramipril combined with valsartan in the treatment of essential hypertension (EH). Methods A total of 102 patients with mild to moderate EH were randomly divided into 3 groups: ramipril group (34 cases) and ramipril 5 mg / d, valsartan group (34 cases) received valsartan 160 mg / d, Group (n = 34) received ramipril 2.5mg plus valsartan 80mg / d for 12 weeks. Before and after treatment regularly measure blood pressure, ambulatory blood pressure, liver and kidney function, blood lipids, blood glucose, etc., to observe the occurrence of adverse reactions. Results The total effective rate was 77.1% in ramipril group and the blood pressure was decreased by 23.9 / 15.8mmHg. The total effective rate was 77.1% in valsartan group and the reduction rate was 24.3 / 15.1mmHg. The total effective rate was 79.4% in ramipril group, 24.4 / 15.2 mmHg. The three groups of drugs can reduce the blood pressure load, and there is no significant difference between the two groups (P> 0.05). There was no significant difference in blood routine, biochemistry, blood lipid, liver and kidney function between the three treatment groups before and after treatment (P> 0.05). There was no significant difference between the two groups in the total adverse reaction rate. Conclusions Ramipril and valsartan combined with EH can effectively and safely reduce blood pressure.