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作者回顾分析了1966年1月—1979年12月间意大利947例何杰金氏病(HD)患者治疗后急性白血病的发病情况。 HD治疗:136例(14.4％)单用放疗(RT),其中40％进行次全或全淋巴结放疗。175例(18.5％)单用化疗(CHT),其中111例(63.4％)用MOPP,28例(16％)用ABVD联合化疗,36例(20.5％)用其它化疗。394例(41.6％)最初用综合治疗:其中335例(85％)用RT加MOPP、28例(7.1％)用RT加ABVD、31例(7.9％)RT加其它CHT。242例(25.5％)综合治疗后用CHT或CHT加RT补救治疗。
The authors retrospectively analyzed the incidence of acute leukemia in 947 Hodgkin’s disease (HD) patients in Italy from January 1966 to December 1979. HD treatment: 136 patients (14.4%) with radiotherapy alone (RT), of which 40% were subtotal or total lymph node radiotherapy. Eleven patients (63.4%) were treated with MOPP, 28 (16%) were treated with ABVD combined with chemotherapy, and 36 (20.5%) were treated with other chemotherapies in 175 patients (18.5%) with chemotherapy alone. Of the 394 patients (41.6%) initially treated with combination therapy, 335 (85%) were treated with RT plus MOPP, 28 (7.1%) with RT plus ABVD and 31 (7.9%) RT with other CHT. 242 cases (25.5%) combined treatment with CHT or CHT plus RT remedial treatment.