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目的：研究幼仓鼠肾（ＢＨＫ）细胞表达红细胞生成素（ＥＰＯ）在猕猴体内的药动学。方法：ＥＬＩＳＡ法测定血清浓度。结果：ｉｖ２００ｕ·ｋｇ－１后符合二室开放模型，ｔ１／２α和ｔ１／２β分别为（１．８±０．３）ｈ和（１１．３±１．７）ｈ。ｓｃ５０，２００和８００ｕ·ｋｇ－１后符合一级吸收一室模型，ｔ１／２Ｋｅ分别为（１０．５±３．２）ｈ、（１０．０±１．３）ｈ和（７．４±１．０）ｈ，吸收速率受剂量限制，ｔ１／２Ｋａ分别为（０．４±０．４）ｈ，（１．１±０．６）ｈ和（１．９±０．６）ｈ（Ｆ＝８．２，Ｐ＜０．０５）。ｔｍａｘ分别为（３．０±１．２）ｈ，（４．０±０．０）ｈ和（５．５±１．９）ｈ。ＡＵＣ随剂量增加，Ｃｌｓ相近，生物利用度为０．６４。结论：ＥＰＯ体内总过程基本符合线性药动学，方法学与结果对人体研究有参考意义
Objective: To study the pharmacokinetics of erythropoietin (EPO) expressed in baby hamster kidney (BHK) cells in rhesus monkeys. Methods: Serum concentration was measured by ELISA. Results: The two-compartment open model iv200u · kg-1, t1 / 2α and t1 / 2β were (1.8 ± 0.3) h and (11.3 ± 1.7) h respectively. The first-order absorption model was sc 500, 200 and 800u · kg-1, respectively, and the t1 / 2Ke were (10.5 ± 3.2) h, (10.0 ± 1.3) h and 1.0) h, the rate of absorption was limited by the dose, t1 / 2Ka were (0.4 ± 0.4) h, (1.1 ± 0.6) h and (1.9 ± 0.6) h F = 8.2, P <0.05). tmax were (3.0 ± 1.2) h, (4.0 ± 0.0) h and (5.5 ± 1.9) h, respectively. AUC increased with dose, Cls similar, bioavailability of 0.64. Conclusion: The overall process of EPO basically accord with the linear pharmacokinetics, and the methodology and results have reference value for human research