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目的:探讨中药蔓荆子中主要成分紫花牡荆素的抗炎作用。方法:通过急性抗炎模型——二甲苯致小鼠耳廓肿胀实验、鸡蛋清致大鼠足跖肿胀实验以及腹腔注射0.7%醋酸致小鼠腹腔毛细血管通透性增高的实验,观察紫花牡荆素的抗炎作用。结果:紫花牡荆素对二甲苯所致小鼠耳廊肿胀、鸡蛋清所致大鼠足肿胀以及醋酸所致小鼠毛细血管通透性增加均有明显的抑制作用。结论:紫花牡荆素具有明显的体内抗炎作用,为蔓荆子抗炎作用的有效成分。
Objective: To investigate the anti-inflammatory effects of vitexin, the main component of Chinese medicine Vitex negundo. METHODS: Through an acute anti-inflammatory model, an xylitol-induced mouse ear swelling test, an egg white-induced rat paw swelling test, and an intraperitoneal injection of 0.7% acetic acid-induced increase in capillary permeability in the abdominal cavity of mice, observe the observation Ethanol’s anti-inflammatory effects. RESULTS: The effect of vitexin on xylene-induced swelling of mouse auricles, the swelling of rats’ feet caused by egg whites, and the increase of capillary permeability of mice induced by acetic acid were significantly inhibited. Conclusion: Albumin has obvious anti-inflammatory effect in vivo and is an effective component of anti-inflammatory effect of Vitex negundo.