双硫仑(disulfiram,商品名为Antabus(?))是戒断酒精中毒的辅助药,它能抑制乙醛脱氢酶。酒精与双硫仑结合导致乙醛的累积,引起如下典型症状:面色潮红、心动过速、呼吸困难、恶心和呕吐。 双硫仑还会引起严重的肝损害。在瑞典药品处方集(FASS)中,肝损害为“一种罕见的不良反应(<1/1000),通常伴有类似急性肝炎/黄疸的症状,及SGOT、SGPT和胆红素升高。”该反应可能是一种过敏,也可能是一种毒性反应。 瑞典药品不良反应登记处(SWEDIS)自1971年 Disulfiram (trade name Antabus (?)) Is an adjunct to alcohol withdrawal, which inhibits aldehyde dehydrogenase. The combination of alcohol and disulfiram causes the accumulation of acetaldehyde, causing typical symptoms such as flushing, tachycardia, dyspnea, nausea and vomiting. Disulfiram can cause severe liver damage. In the Swedish Drug Prescription Set (FASS), liver damage is “a rare adverse event (<1/1000) usually accompanied by symptoms similar to acute hepatitis / jaundice and elevated SGOT, SGPT and bilirubin.” The reaction may be an allergy, it may be a toxic reaction. Swedish Drug Adverse Reactions Registry (SWEDIS) since 1971