We demonstrated here a new family of multi-responsive polymer:wholly aromatic sulfonated polyamide(SPA).SPA exhibited the unusual response to temperature and pH with the tunable low critical solution temperature(LCST).LCST of the obtained SPA decreased sharply with the increasing pH,and the difference of LCST between pH 6.0-6.8 is about 60 ℃. We demonstrated here a new family of multi-responsive polymers: exclusively aromatic sulfonated polyamide (SPA). SPA showed the unusual response to temperature and pH with the tunable low critical solution temperature (LCST). LCST of the obtained SPA decreased sharply with the increasing pH, and the difference of LCST between pH 6.0-6.8 is about 60 ° C.