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目的探讨原发灶不明恶性肿瘤的诊断、治疗方式和预后因素。方法回顾分析我院1999年9月—2007年10月收治的32例原发灶不明恶性肿瘤患者的临床资料。结果全组的1、2、3年生存率分别为65.6%、43.8%、28.1%,中位生存时间为12.5个月;行化放疗综合治疗的患者在近期疗效(73.3%)和中位生存时间(15.5个月)方面均优于其他治疗方式;6例转移性鳞癌患者,23例转移性腺癌患者的中位生存时间分别为17.0个月,9.5个月;仅表现为周围淋巴结转移及浅表肿块的患者与表现为实质脏器转移及恶性体腔积液的患者的中位生存时间分别为15.5个月,10.0个月,7.5个月。结论对原发灶不明恶性肿瘤应加强认识和积极治疗;治疗上应根据性别、病理类型、转移部位给予以化、放疗为主的综合治疗;影响预后的主要因素为治疗方式、病理类型及转移癌部位。
Objective To investigate the diagnosis, treatment and prognostic factors of malignant tumor with unknown primary tumor. Methods The clinical data of 32 patients with malignant primary tumor who were admitted to our hospital from September 1999 to October 2007 were retrospectively analyzed. Results The overall 1, 2, 3-year survival rates were 65.6%, 43.8% and 28.1%, respectively, and the median survival time was 12.5 months. The short-term efficacy (73.3%) and median survival (15.5 months). The median survival time was 17.0 months and 9.5 months in 6 cases of metastatic squamous cell carcinoma and 23 cases of metastatic adenocarcinoma respectively. Only the peripheral lymph node metastasis and The median survival time was 15.5 months, 10.0 months and 7.5 months in patients with superficial lumps and those with solid organ metastases and malignant effusions, respectively. Conclusion The treatment of malignant tumors with unknown primary tumors should be strengthened and actively treated. The treatment should be based on gender, pathological type, metastasis site to give comprehensive treatment of radiotherapy, and the main factors affecting the prognosis of treatment, pathological type and metastasis Cancer site.