心脏肥大细胞分泌的糜酶是近年发现的一种糜蛋白样的丝氨酸蛋白酶,广泛分布于心肌间质。自从发现血管紧张素Ⅱ(AngⅡ)生成的旁路途径以来,糜酶与心血管疾病的关系日益受到关注[1],本文就国内外研究进展综述如下。1糜酶的分子结构及生物学特性糜酶最早发现于肥大细胞,因其结构与 Chymase, which is secreted by cardiac mast cells, is a chymotrypsin-like serine protease found in recent years and widely distributed in cardiac interstitium. The relationship between chymase and cardiovascular diseases has been paid more and more attention since the discovery of the bypass pathway of angiotensin Ⅱ (AngⅡ). This article reviews the research progress at home and abroad. 1 chymase molecular structure and biological characteristics chymase was first found in mast cells, because of its structure and