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目的:探究在首发急性脑梗死患者中采用尤瑞克林针联合中药治疗的效果及其对患者局部脑血流的影响,为提高该类患者的疗效提供实践依据。方法:将我院2011年1月—2013年12月收治的100例首发急性脑梗死患者,按照随机数表法分成观察组与对照组,每组均50例,两组患者均给予脱水、脑保护、降颅内压、改善脑部循环等常规治疗及对症治疗,对照组患者给予尤瑞克林针治疗,治疗组在对照组基础上加用中药治疗,比较两组患者临床疗效、治疗前后的血液流变学指标及不良反应发生情况。结果:观察组治疗后的总有效率为96.00%,显著高于对照组的72.00%,差异有统计学意义(P<0.05);两组患者治疗前的血液流变学指标(全血黏度、血浆黏度、红细胞压积及纤维蛋白原)对比,差异无显著性(P>0.05),但观察组治疗后的各项血液流变学指标水平均显著低于对照组,差异均有显著性(P<0.05);两组患者治疗后均未出现明显的不良反应症状。结论:在首发急性脑梗死患者中采用尤瑞克林针联合中药治疗,可有效提高临床疗效、改善患者的局部脑血流,安全性高,具有一定的临床应用价值。
Objective: To investigate the effect of Urelin on traditional Chinese medicine in patients with first-episode acute cerebral infarction and its effect on the regional cerebral blood flow in patients with acute cerebral infarction, and to provide a practical basis for improving the curative effect of such patients. Methods: One hundred patients with acute cerebral infarction who were admitted to our hospital from January 2011 to December 2013 were divided into observation group and control group according to random number table. Each group had 50 cases. Both groups were given dehydration, brain Protection, reduce intracranial pressure, improve brain circulation and other conventional treatment and symptomatic treatment, the control group of patients given urelin needle treatment, the treatment group in the control group based on the use of traditional Chinese medicine treatment, the clinical efficacy of the two groups were compared before and after treatment Hemorheology indicators and adverse reactions. Results: The total effective rate of the observation group after treatment was 96.00%, which was significantly higher than that of the control group (72.00%), the difference was statistically significant (P <0.05); before treatment, the hemorheological parameters (whole blood viscosity, Plasma viscosity, hematocrit and fibrinogen), the difference was not statistically significant (P> 0.05), but the levels of hemorheology in the observation group were significantly lower than those in the control group, the difference was significant P <0.05). No significant adverse reaction symptoms occurred in both groups after treatment. Conclusion: The combination of uracil needle and traditional Chinese medicine in patients with first-episode acute cerebral infarction can effectively improve the clinical curative effect, improve the local cerebral blood flow, have high safety and have certain clinical value.