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目的:旨在观察18月-24月龄幼儿在接种上海麻腮风三联疫苗时的疼痛反应是否较接种MMR-Ⅱ为轻。方法:根据随机双盲的原则将幼儿分入上海麻腮风三联疫苗组和MMR-Ⅱ组。而后,分别由研究人员(使用《儿童医院低龄儿童痛疼评分表》)和幼儿的家长(使用VAS量表)观察幼儿在接种疫苗时的疼痛反应。结果:本研究一共观察了295名幼儿。上海麻腮风三联疫苗组和MMR-Ⅱ组的VAS平均得分分别是2.3和5.2(P<0.001),《儿童医院低龄儿童痛疼评分表》平均得分分别是1.92和6.14(P<0.001)。结论:幼儿接种上海麻腮风三联疫苗时的疼痛反应要较接种MMR-Ⅱ轻。
OBJECTIVE: To investigate whether the pain response of infants vaccinated with Shanghai MMR vaccine from 18 months to 24 months is lighter than MMR-II. Methods: According to the principle of randomized double blind, young children were divided into Shanghai MMR vaccine group and MMR-Ⅱ group. Subsequently, the pain responses of young children at the time of vaccination were observed by the researchers (using the Children’s Hospital Young Scientist Pain Scale) and the young parent (using the VAS scale), respectively. Results: A total of 295 young children were observed in this study. The average VAS scores of Shanghai MMR vaccine group and MMR-Ⅱ group were 2.3 and 5.2, respectively (P <0.001). The average score of the Children and Adolescent Hospital Pain Rating Scale was 1.92 and 6.14 (P <0.001), respectively. Conclusion: The pain response of young children vaccinated with Shanghai MMR vaccine is lighter than MMR-Ⅱ.